Unraveling inhibitory effects of NSAIDs on innate immune response

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K14951
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Biological pharmacy
• Research Institution: The University of Tokushima
• Principal Investigator: SAITOH Tatsuya 徳島大学, 先端酵素学研究所(次世代), 教授 (60456936)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 抗炎症薬 / NSAIDs / 痛風 / 自然免疫 / サイトカイン

Outline of Final Research Achievements

NLRP3-inflammasome, an innate immune system, is activated by monosodium urate crystals, and is involved in gout attack. NLRP3-inflammasome is also activated by metabolites such as cholesterol crystals and free fatty acids, and causes the development of lifestyle diseases. Therefore, NLRP3-inflammasome is considered as a target of therapy and drug development of lifestyle diseases. We have examined the effects of non-steroidal anti-inflammatory drugs (NSAIDs), which are used during a gout attack, on NLRP3-inflammasome, and found that they exert their pharmacological effects through different modes of action.

Free Research Field

生物系薬学