2016 Fiscal Year Final Research Report
Control of epigenetics by chemical modulator based on natural products
Project/Area Number |
15K14974
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Drug development chemistry
|
Research Institution | Hokkaido University |
Principal Investigator |
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Project Period (FY) |
2015-04-01 – 2017-03-31
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Keywords | エピジェネティックス / 創薬化学 / 抗がん剤 |
Outline of Final Research Achievements |
Analogues of DNA bisintercalating natural products were designed and synthesized and their DNA binding properties as well as cytotoxicity against human cancer cells were evaluated. Several analogues exhibit a potent cytotoxicity against a panel of human cancer cells with nM level and some of the analogues also show in vivo antitumor activity in the experiments using mouse xenograft model. As a result, we were able to find a promising anticancer lead compound.
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Free Research Field |
創薬化学
|