Medication for pregnant women based on 'barrier transition' behavior in feto-placental circulation

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K15007
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Medical pharmacy
• Research Institution: Keio University
• Principal Investigator: Tomi Masatoshi 慶應義塾大学, 薬学部(芝共立), 教授 (30334717)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 胎盤関門 / miRNA

Outline of Final Research Achievements

We have clarified the developmental change in the placental transporters such as glucose transporter 1 (GLUT1) and monocarboxylate transporter 1 (MCT1), while the expressions of ABC transporters such as MDR1 and BCRP were unchanged during pregnancy. We also found a placenta-derived miRNA which may work for maturation of both placental and blood-brain barrier. These observations are helpful for examining the interorgan network in the fetoplacental circulation for establishing and managing barriers in the placenta and the brain.

Free Research Field

薬物動態学