Neuronal network analysis of hierarchical alteration in juveniles rat

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K15041
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Environmental physiology(including physical medicine and nutritional physiology)
• Research Institution: National Center for Geriatrics and Gerontology
• Principal Investigator: TADA Hirobumi 国立研究開発法人国立長寿医療研究センター, 統合加齢神経科学研究部, 室長 (20464993)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 優劣性交互関係 / 内側前頭前野

Outline of Final Research Achievements

Individuals exposed early in life to social separation, one form of neglect, develop impaired interpersonal relationships, including aggressive behaviors and social hierarchy. Although there is evidence that functional circuits in the medial prefrontal cortex (mPFC) regulate social behaviors, the effect of social separation early in life on neural circuit development in the mPFC is not well understood. Here, we found the mPFC neural mechanisms that isolation of neonatal rats altered social hierarchy and aggression in juveniles.

Free Research Field

分子神経内分泌学