Elucidation of the molecular mechanism of the multifaceted action of DOACs through cyclophilin A receptor

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K15046
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: General pharmacology
• Research Institution: Tohoku University
• Principal Investigator: SATOH Kimio 東北大学, 高度教養教育・学生支援機構, 准教授 (80436120)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 新規抗凝固薬 / サイクロフィリンA / 酸化ストレス / 血管内皮障害 / 動脈硬化 / 血小板活性化 / 血栓塞栓症 / 冠動脈疾患

Outline of Final Research Achievements

We are studying the possibility of multifaceted action via inhibitory action of cyclophillin A (CyPA) and its receptor, basigin, by new anticoagulants (DOACs). The significance in the proinflammatory action of the CyPA-Basigin system and the vascular remodeling mechanism, which has not been known at all, has been elucidated, and preparations for publication of the paper are underway. Very interesting findings have been obtained on the possibility of new pharmacological actions of DOACs. We reported these findings and results at international scientific conferences and symposiums both in Japan and abroad (Symposium in the Japanese Circulation Society Annual Scientific meeting, the American Heart Association Annual Scientific meeting, and the European Society of Cardiology Annual Scientific meeting).

Free Research Field

医歯薬学