2017 Fiscal Year Final Research Report
Optical Regulation of exciteing cells
| Project/Area Number |
15K15072
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General medical chemistry
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| Research Institution | Dokkyo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 光刺激 / 光応答 / 心筋細胞 / 興奮性 / アゾ化合物 |
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| Outline of Final Research Achievements |
We conducted a study to control the activities of cells of several organisms, such as exciting cardiomyocytes, by light irradiation with simple photo-sensitive molecules. When the photosensitizing substance was present in the extracellular liquid phase, electron-microscopic observation showed that the cell membrane structure reversibly changed depending on the wavelength of the irradiated ligh. It is suggested that such changes of the cellular activities are modifying by changing property of the membrane by irraidiating light. One of the application of the system, micron-scaled power source for microactuators and so one will be realized.
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| Free Research Field |
生命科学
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