2016 Fiscal Year Final Research Report
Development of liquid biopsy against dementia
| Project/Area Number |
15K15100
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Human pathology
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | Dementia / Alzheimer's disease / microRNA / liquid biopsy / exosome |
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| Outline of Final Research Achievements |
Dementia is of one the intractable disease that is characterize neurodegeneration. And the number of patients of Alzheimer's disease(AD) is rapidly growing in world wide. Problematic point of AD, the etiology of the is still poorly understood. In addition, we do not have early detection marker of AD and effective drug against AD. MicroRNAs are a family of 19- to 25-nucleotides noncoding small RNAs that primarily function as gene regulators. Aberrant microRNA expression has been observed human disease including human malignancies. Despite this knowledge, there is little information regarding microRNAs in plasma AD patient. In this project, we focused circulating miRNA in AD and whether expression levels of specific microRNAs differ between AD and healthy individuals. And we found some miRNA of plasma was highly expressed in AD patient. These miRNAs have strong potential for clinical application as a novel biomarker for detection of AD.
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| Free Research Field |
分子病理学
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