Involvement of neutrophil extracellular traps in the development of diabetic angiopathy

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K15105
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Experimental pathology
• Research Institution: Hokkaido University
• Principal Investigator: Akihiro Ishizu 北海道大学, 保健科学研究院, 教授 (60321957)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 糖尿病血管障害 / 微小炎症 / 好中球細胞外トラップ

Outline of Final Research Achievements

Recent studies have demonstrated that high-dose glucose induces neutrophil extracellular trap (NET) formation which can be a risk for microvascular disorders. Thus, we attempted to determine the correlation of circulating NET levels and clinical/laboratory parameters in well-controlled T2D patients and to reveal the mechanism of NET formation induced by high-dose glucose.　As a result, serum MPO-DNA complex levels that represent the NET formation in vivo were significantly higher in some well-controlled T2D patients in correlation with the clinical/laboratory parameters, which have been regarded as risk markers for microvascular complications. The aldose reductase inhibitor, ranirestat, could inhibit the NET formation induced by high-dose glucose. These findings suggest that elevated levels of circulating NETs can be a risk marker for microvascular complications in well-controlled T2D patients, and that the polyol pathway is involved in the NET formation induced by high-dose glucose.

Free Research Field

病理学