2016 Fiscal Year Final Research Report
Visualization of bacteria-induced autophagy by live-imaging.
Project/Area Number |
15K15130
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Bacteriology (including mycology)
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Research Institution | Kyoto University |
Principal Investigator |
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Project Period (FY) |
2015-04-01 – 2017-03-31
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Keywords | A群レンサ球菌 / オートファジー / イメージング / Rabタンパク質 |
Outline of Final Research Achievements |
In this study, we selected a probe for visualization of infection step using group A Streptococcus as a model, and introduced a multidimensional fluorescence imaging system. We found that Rab 17, Rab 30 and Rab35 could colocalized to bacteria-induced autophagosome specifically. In particular, it was revealed that Rab 35 was involved in the formation of bacteria-induced autophagosomes by direct binding to NDP 52, which is an adapter protein. These results indicate that some specific Rab proteins are important for bacteria-induced autophagy.
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Free Research Field |
細菌学
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