Studies on new host-pathogen interaction via bacterial protease

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K15131
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Bacteriology (including mycology)
• Research Institution: Osaka University
• Principal Investigator: Arase Hisashi 大阪大学, 微生物病研究所, 教授 (10261900)
• Co-Investigator(Renkei-kenkyūsha): HIRAYASU Kouyuki 大阪大学, 免疫学フロンティア研究センター, 特任助教(常勤) (30585170) ; KATAYAMA Ichiro 大阪大学, 医学系研究科, 教授 (80191980)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: プロテアーゼ / LILRA2 / 免疫逃避 / 生体防御 / レジオネラ / マイコプラズマ

Outline of Final Research Achievements

Certain bacteria inactivate antibody by cutting variable region of antibody. Furthermore, we found that such truncated antibodies are recognized by immune activating receptor, LILRA2. Truncated antibodies specifically activated neutrophils expressing LILRA2. In addition, growth of Legionella in monocytes were suppressed by stimulation with truncated antibodies. These results suggested that LILRA2 plays an important role in host defense by recognizing truncated antibodies.

Free Research Field

免疫学