Identification of receptor for cell-to-cell infection of HSV

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K15138
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Virology
• Research Institution: The University of Tokyo
• Principal Investigator: Arii Jun 東京大学, 医科学研究所, 助教 (30704928)
• Co-Investigator(Renkei-kenkyūsha): KAWAGUCHI Yasushi 東京大学, 医科学研究所, 教授 (60292984)
• Research Collaborator: KATO Akihisa 東京大学, 医科学研究所, 助教 ; KOYANAGI Naoto 東京大学, 医科学研究所, 特任研究員
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: HSV / glycoprotein / 膜タンパク質 / 細胞間感染

Outline of Final Research Achievements

We investigated the mechanism of HSV cell-to-cell infection and identified new cellular factor which promotes cell-to-cell infection of HSV. This protein was interacted with viral gE, which is kwon to be important for cell-to-cell infection. Moreover, this protein was required for gE-dependent cell-to-cell infection. Thus, understanding of molecular mechanism of cell-to-cell infection of HSV may indicate new prophylactic and therapeutic approaches for the development of antiherpetic drugs.

Free Research Field

ウイルス学