DEVELOPMENT OF OPTICAL CONTROLLABLE NOVEL MEASLES VIRUS VECTOR

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K15145
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Virology
• Research Institution: National Institute of Infectious Diseases
• Principal Investigator: TAHARA MAINO 国立感染症研究所, ウイルス第三部, 主任研究官 (10572109)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 麻疹ウイルス / ウイルスベクター / 遺伝子治療 / 再生医療

Outline of Final Research Achievements

Measles virus (MeV) vector can transfer multiple genes into human cells efficiently without affecting the host genome. We recently have developed novel MeV gene transfer vector which is non-transmissible, can transfer multiple genes simultaneously. We could successfully generate induced pluripotent stem cells from human fibroblasts or peripheral blood T cells using this vector.
Although MeV as gene transfer vector is clearly beneficial, no method has been developed to control viral growth. We set out to design a method of controlling viral growth. Now, we developed optically controllable MeV. We believe our new optically controllable MeV vector has the potential to revolutionize gene transfer technologies.

Free Research Field

ウイルス学