Identification of human DC and monocyte progenitors

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K15150
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Immunology
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: OHTEKI Toshiaki 東京医科歯科大学, 難治疾患研究所, 教授 (50233200)
• Co-Investigator(Renkei-kenkyūsha): ONAI Nobuyuki 東京医科歯科大学, 難治疾患研究所, 講師 (50323605)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: ヒトcMop / 単球/マクロファージ / cGMP / rGMP

Outline of Final Research Achievements

Dendritic cells and monocytes/macrophages are critically involved in host defense and tissue pathology under steady-state and inflammatory conditions. A common monocyte progenitor (cMoP) that is strictly committed to the monocyte lineage has been recently identified in mice. In this study, we identified human cMoPs as a CLEC12AhiCD64hi subpopulation of conventional granulocyte-monocyte progenitors (cGMPs) in umbilical cord blood and in bone marrow. Human cMoPs gave rise to monocyte subsets without showing any potential for differentiating into myeloid or lymphoid cells. Within the cGMP population, we also identified revised GMPs that completely lacked DC and lymphoid potential. Our findings expand and revise the current understanding of human myeloid cell differentiation pathways.

Free Research Field

免疫学