2016 Fiscal Year Final Research Report
Analysis of human intestinal microbiota
| Project/Area Number |
15K15152
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Immunology
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
NAKAMURA Shota 大阪大学, 微生物病研究所, 特任准教授 (90432434)
|
|---|
| Research Collaborator |
MAEDA Yuichi
|
|---|
| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Keywords | 関節リウマチ / 腸内細菌 / 免疫 |
|---|
| Outline of Final Research Achievements |
Composition of intestinal microbiota has been shown to be altered in several disorders including rheumatoid arthritis (RA). However, it remained unknown whether the altered composition of microbiota is a result or cause of RA. We found that a subpopulation of RA patients harbored Prevotella-dominated intestinal microbiota. We analyzed the altered composition of microbiota dominated by Prevotella contributes to the pathogenesis of arthritis in arthritis-prone SKG mice, which did not develop arthritis in the absence of microbiota. Germ-free SKG mice were colonized with human microbiota (RA-type and healthy control (HC)-type microbiota). RA-SKG mice developed severe arthritis compared to SKG mice harboring HC microbiota. The number of Th17 cells in regional lymph nodes and the colon was increased in RA-SKG mice. Thus altered composition of microbiota contributes to the pathogenesis of arthritis.
|
| Free Research Field |
免疫学
|
