2017 Fiscal Year Annual Research Report
Identification of Genes Controlling Treg Development by Combining the CRISPR-Cas9 System and Bone Marrow Chimeric Mouse Model
| Project/Area Number |
15K15154
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| Research Institution | Osaka University |
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Principal Investigator |
Jun Huang 大阪大学, 免疫学フロンティア研究センター, 特任研究員(常勤) (00751207)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | Regulatory T cells / epigenetics / immune tolerance / autoimmune diseases |
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| Outline of Annual Research Achievements |
Regulatory T cells (Tregs) play an indispensable role in maintaining immune homeostasis. Understanding the molecular basis governing their development will help to understand the pathogenesis of autoimmune diseases and establish new strategies for the treatment and prevention of immunological diseases. We found that Mbd3 plays an essential role in thymic Treg development, and thus establishment of immune homeostasis. Our findings expand the notion that the defects in genetic and epigenetic control of thymic Tregs development could be potentially the cause of a wide range of autoimmune diseases.
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