Fundamental Study on Preparations for Therapeutic Antibodies with Less Productions of Anti-Drug Antibodies

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K15184
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Applied pharmacology
• Research Institution: Kyushu University
• Principal Investigator: Ueda Tadashi 九州大学, 薬学研究院, 教授 (90184928)
• Co-Investigator(Kenkyū-buntansha): 日下部 宜宏 九州大学, 農学研究院, 教授 (30253595) ; 宗 孝紀 東北大学, 医学系研究科, 准教授 (60294964) ; 阿部 義人 九州大学, 薬学研究院, 准教授 (60315091) ; 白石 充典 九州大学, 薬学研究院, 助教 (00380527)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: antibody / stability / immunolgy / Anti-Drug Antibodies / Derp2 / Fab

Outline of Final Research Achievements

Anti-Drug Antibodies (ADAs) are often found in patients whom therapeutic antibodies are administrated. ADAs will lead the attenuation of medical effects of therapeutic antibodies. From the standpoints of reduction in medical costs, we should develop the method to depress ADAs as early as possible. In order to depress ADAs in general, we focus on the constant region of humanized Fab, which are common in therapeutic antibodies. In this study, we prepared the humanized Fab with different conformational stability by the modification of the constant regions and examined the immunogenicities of these human Fab with different conformational stabilities.

Free Research Field

応用薬理学、抗体工学