メンデル無作為化解析による胎児期環境リスク評価と遺伝・環境交互作用

2016 Fiscal Year Research-status Report

• Project/Area Number: 15K15220
• Research Institution: Chuo University
• Principal Investigator: 佐田 文宏 中央大学, 保健センター, 常勤嘱託医師 (90187154)
• Co-Investigator(Kenkyū-buntansha): 岸 玲子 北海道大学, 環境健康科学研究教育センター, センター特別招へい教授 (80112449) ; 荒木 敦子 北海道大学, 環境健康科学研究教育センター, 准教授 (00619885)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 環境疫学 / メンデル無作為化解析 / DOHaD学説 / 胎児期リスク評価 / 遺伝・環境交互作用

Outline of Annual Research Achievements

１）北海道スタディの質問紙調査・出産時個票から、両親の喫煙状況及び児の身長・体重等の発育等に関するデータ、北海道スタディで、測定した化学物質のデータ（PCB・ダイオキシン類、水酸化PCB、有機フッ素系化合物（PFOS, PFOA他）、葉酸等）を入手し、解析に用いた。
２）北海道スタディで、測定した臍帯血ホルモン濃度のデータ（エストラジオ－ル、総テストステロン、プロゲステロン、黄体形成ホルモン、卵胞刺激ホルモン、性ホルモン結合グロブリン、プロラクチン、Inhibin B、INSL3を入手し、解析に用いた。
３）発育に関しては、体重，身長，頭囲，胸囲，BMI，Ponderal Index，低出生体重，SGA，小児肥満等を、性分化・性腺機能に関しては、第２指・第４指比，肛門性器間距離，陰茎長（男児），精巣体積（男児）等をアウトカムとして解析に用いた。
４）異物・ステロイド代謝酵素・受容体・結合蛋白遺伝子、GWASで報告されている性ホルモン濃度、SHBG濃度との関連のあるSNP、GWASで報告されている小児の発育・出生体重との関連のあるSNPの中から、機能変化が証明されたもの、疾患との関連のエビデンスが確実なものから、メンデルランダム化解析の際、環境曝露の代用となり得る可能性のある候補を選定した。
５）メンデルランダム化解析は、従来の観察疫学研究（コホート研究・症例対照研究）の持つバイアス不可避性や逆因果性という限界を乗り越えられる利点があるとされている。既に、欧州の出生コホート（ALSPAC）において、肥満関連遺伝子（FTO, MC4R, TEM18, GNPDA4）の４SNPを用いて、疾患リスクを低下させる操作変数としての検討が行われている。本研究では、このような肥満関連遺伝子と性ホルモン関連遺伝子を中心に選定し、解析を進めている。

Current Status of Research Progress

3: Progress in research has been slightly delayed.

Reason

研究代表者の所属機関の変更に伴い、セットアップに時間がかかったこと、北海道大学環境健康科学研究教育センターで実験を行うため、研究者間で調整が必要であったこと及び欠損値等に関して追加実験が必要であったこと等による。

Strategy for Future Research Activity

研究の協力体制が整ってきたので、分担研究者、研究協力者との連携を密にし、研究を進める。今後は、追加のデータの解析を進めるとともに成果の取りまとめにも十分に時間を割く予定である。

Causes of Carryover

遺伝子多型の解析は北海道大学で実施するため、研究者間の調整と準備に時間がかかった。

Expenditure Plan for Carryover Budget

追加解析の実施と成果発表のために使用する予定である。

Research Products

• [Journal Article] Associated factors of behavioural problems in children at preschool age: the Hokkaido study on environment and children's health. (2017)
  • Author(s): Minatoya M, Itoh S, Araki A, Tamura N, Yamazaki K, Nishihara S, Miyashita C, Kishi R.
  • Journal Title: Child Care Health Dev Volume: 43 Pages: 385-392
  • DOI: 10.1111/cch.12424
  • Peer Reviewed
• [Journal Article] Effects of prenatal perfluoroalkyl acid exposure on cord blood IGF2/H19 methylation and ponderal index: The Hokkaido Study. (2017)
  • Author(s): Kobayashi S, Azumi K, Goudarzi H, Araki A, Miyashita C, Kobayashi S, Itoh S, Sasaki S, Ishizuka M, Nakazawa H, Ikeno T, Kishi R.
  • Journal Title: J Expo Sci Environ Epidemiol Volume: 27 Pages: 251-259
  • DOI: 10.1038/jes.2016.50
  • Peer Reviewed
• [Journal Article] Prenatal exposure to perfluoroalkyl acids and prevalence of infectious diseases up to 4years of age. (2017)
  • Author(s): Goudarzi H, Miyashita C, Okada E, Kashino I, Chen CJ, Ito S, Araki A, Kobayashi S, Matsuura H, Kishi R.
  • Journal Title: Environ Int Volume: - Pages: in press
  • DOI: 10.1016/j.envint.2017.01.024
  • Peer Reviewed
• [Journal Article] Interaction of maternal caffeine intake during pregnancy and CYP1A2 C164A polymorphism affects infant birth size in the Hokkaido Study. (2017)
  • Author(s): Sasaki S, Limpar M, Sata F, Kobayashi S, Kishi R.
  • Journal Title: Pediatr Res Volume: - Pages: in press
  • DOI: 10.1038/pr.2017.70
  • Peer Reviewed
• [Journal Article] Association of prenatal exposure to perfluoroalkyl substances with cord blood adipokines and birth size: The Hokkaido Study on environment and children's health. (2017)
  • Author(s): Minatoya M, Itoh S, Miyashita C, Araki A, Sasaki S, Miura R, Goudarzi H, Iwasaki Y, Kishi R.
  • Journal Title: Environ Res Volume: 156 Pages: 175-182
  • DOI: 10.1016/j.envres.2017.03.033
  • Peer Reviewed
• [Journal Article] Prenatal di(2-ethylhexyl) phthalate exposure and disruption of adrenal androgens and glucocorticoids levels in cord blood: The Hokkaido Study. (2017)
  • Author(s): Araki A, Mitsui T, Goudarzi H, Nakajima T, Miyashita C, Itoh S, Sasaki S, Cho K, Moriya K, Shinohara N, Nonomura K, Kishi R.
  • Journal Title: Sci Total Environ Volume: 581-582 Pages: 297-304
  • DOI: 10.1016/j.scitotenv.2016.12.124
  • Peer Reviewed
• [Journal Article] Prenatal di-2-ethylhexyl phthalate exposure and cord blood adipokine levels and birth size: The Hokkaido study on environment and children's health. (2017)
  • Author(s): Minatoya M, Araki A, Miyashita C, Sasaki S, Goto Y, Nakajima T, Kishi R.
  • Journal Title: Sci Total Environ. 2017 Feb 1;579:. Volume: 579 Pages: 606-611
  • DOI: 10.1016/j.scitotenv.2016.11.051
  • Peer Reviewed
• [Journal Article] The Association of Prenatal Exposure to Perfluorinated Chemicals with Glucocorticoid and Androgenic Hormones in Cord Blood Samples: The Hokkaido Study. (2017)
  • Author(s): Goudarzi H, Araki A, Itoh S, Sasaki S, Miyashita C, Mitsui T, Nakazawa H, Nonomura K, Kishi R.
  • Journal Title: Environ Health Perspect Volume: 125 Pages: 111-118
  • DOI: 10.1289/EHP142
  • Peer Reviewed
• [Journal Article] Dioxin-metabolizing genes in relation to effects o prenatal dioxin levels and reduced birth size: The Hokkaido study. (2017)
  • Author(s): Kobayashi S, Sata F, Miyashita C, Sasaki S, Ban S, Araki A, Goudarzi H, Kajiwara J, Todaka T, Kishi R.
  • Journal Title: Reprod Toxicol Volume: 67 Pages: 111-116
  • DOI: 10.1016/j.reprotox.2016.12.002
  • Peer Reviewed
• [Journal Article] 21世紀出生児縦断調査の概要：児の発育に影響を及ぼす要因． (2017)
  • Author(s): 佐田文宏，福岡秀興，尾崎貴視，伊藤善也，吉池信男，瀧本秀美．
  • Journal Title: 日本衛生学雑誌 Volume: 72 Pages: 15-19
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 【講座 子どもを取り巻く環境と健康】第24回 誰もが健康な人生のスタートを：世界で進む出生コーホート研究． (2017)
  • Author(s): 岸 玲子， 湊屋街子，荒木敦子，宮下ちひろ．
  • Journal Title: 公衆衛生 Volume: 81 Pages: 175-183
• [Journal Article] Quantifying bisphenol A in maternal and cord whole blood using isotope dilution liquid chromatography/tandem mass spectrometry and maternal characteristics associated with bisphenol A. (2016)
  • Author(s): Yamamoto J, Minatoya M, Sasaki S, Araki A, Miyashita C, Matsumura T, Kishi R.
  • Journal Title: Chemosphere Volume: 164 Pages: 25-31
  • DOI: 10.1016/j.chemosphere.2016.08.001
  • Peer Reviewed
• [Journal Article] Evaluation of the Japanese Metabolic Syndrome Risk Score (JAMRISC): a newly developed questionnaire used as a screening tool for diagnosing metabolic syndrome and insulin resistance in Japan. (2016)
  • Author(s): Tan C, Sasagawa Y, Kamo KI, Kukitsu T, Noda S, Ishikawa K, Yamauchi N, Saikawa T, Noro T, Nakamura H, Takahashi F, Sata F, Tada M, Kokai Y.
  • Journal Title: Environ Health Prev Med Volume: 21 Pages: 470-479
  • DOI: 10.1007/s12199-016-0568-5
  • Peer Reviewed
• [Journal Article] Exposure to phthalates in house dust and associated allergies in children aged 6-12years. (2016)
  • Author(s): Ait Bamai Y, Araki A, Kawai T, Tsuboi T, Saito I, Yoshioka E, Cong S, Kishi R.
  • Journal Title: Environ Int Volume: 96 Pages: 16-23
  • DOI: 10.1016/j.envint.2016.08.025
  • Peer Reviewed
• [Journal Article] Combined effects of AHR, CYP1A1, and XRCC1 genotypes and prenatal maternal smoking on infant birth size: Biomarker assessment in the Hokkaido Study. (2016)
  • Author(s): Kobayashi S, Sata F, Sasaki S, Braimoh TS, Araki A, Miyashita C, Goudarzi H, Kobayashi S, Kishi R.
  • Journal Title: Reprod Toxicol Volume: 65 Pages: 295-306
  • DOI: 10.1016/j.reprotox.2016.08.020
  • Peer Reviewed
• [Journal Article] Effects of prenatal phthalate exposure on thyroid hormone levels, mental and psychomotor development of infants: The Hokkaido Study on Environment and Children's Health. (2016)
  • Author(s): Minatoya M, Naka Jima S, Sasaki S, Araki A, Miyashita C, Ikeno T, Nakajima T, Goto Y, Kishi R.
  • Journal Title: Sci Total Environ Volume: 565 Pages: 1037-1043
  • DOI: 10.1016/j.scitotenv.2016.05.098
  • Peer Reviewed
• [Journal Article] Effects of prenatal exposure to perfluoroalkyl acids on prevalence of allergic diseases among 4-year-old children. (2016)
  • Author(s): Goudarzi H, Miyashita C, Okada E, Kashino I, Kobayashi S, Chen CJ, Ito S, Araki A, Matsuura H, Ito YM, Kishi R.
  • Journal Title: Environ Int Volume: 94 Pages: 124-132
  • DOI: 10.1016/j.envint.2016.05.020
  • Peer Reviewed
• [Journal Article] Association of perfluoroalkyl substances exposure in utero with reproductive hormone levels in cord blood in the Hokkaido Study on Environment and Children's Health. (2016)
  • Author(s): Itoh S, Araki A, Mitsui T, Miyashita C, Goudarzi H, Sasaki S, Cho K, Nakazawa H, Iwasaki Y, Shinohara N, Nonomura K, Kishi R.
  • Journal Title: Environ Int Volume: 94 Pages: 51-59
  • DOI: 10.1016/j.envint.2016.05.011
  • Peer Reviewed
• [Journal Article] Effects of adrenal androgens during the prenatal period on the second to fourth digit ratio in school-aged children. (2016)
  • Author(s): Mitsui T, Araki A, Goudarzi H, Miyashita C, Ito S, Sasaki S, Kitta T, Moriya K, Cho K, Morioka K, Kishi R, Shinohara N, Takeda M, Nonomura K.
  • Journal Title: Steroids Volume: 113 Pages: 46-51
  • DOI: 10.1016/j.steroids.2016.06.009
  • Peer Reviewed
• [Journal Article] The Association between Prenatal Yoga and the Administration of Ritodrine Hydrochloride during Pregnancy: An Adjunct Study of the Japan Environment and Children's Study. (2016)
  • Author(s): Kawanishi Y, Saijo Y, Yoshioka E, Nakagi Y, Yoshida T, Miyamoto T, Sengoku K, Ito Y, Miyashita C, Araki A, Kishi R.
  • Journal Title: PLoS One Volume: 11 Pages: e0158155
  • DOI: 10.1371/journal.pone.0158155
  • Peer Reviewed
• [Journal Article] Predictors of folate status among pregnant Japanese women: the Hokkaido Study on Environment and Children's Health, 2002-2012. (2016)
  • Author(s): Yila TA, Araki A, Sasaki S, Miyashita C, Itoh K, Ikeno T, Yoshioka E, Kobayashi S, Goudarzi H, Baba T, Braimoh T, Minakami H, Endo T, Sengoku K, Kishi R.
  • Journal Title: Br J Nutr Volume: 115 Pages: 2227-2235
  • DOI: 10.1017/S0007114516001628
  • Peer Reviewed
• [Journal Article] The Relationship between the Second-to-Fourth Digit Ratio and Behavioral Sexual Dimorphism in School-Aged Children. (2016)
  • Author(s): Mitsui T, Araki A, Miyashita C, Ito S, Ikeno T, Sasaki S, Kitta T, Moriya K, Cho K, Morioka K, Kishi R, Shinohara N, Takeda M, Nonomura K.
  • Journal Title: PLoS One Volume: 11 Pages: e0146849
  • DOI: 10.1371/journal.pone.0146849
  • Peer Reviewed
• [Journal Article] 発達期環境に起因する疾患素因の形成機構―DOHaDの視点から． (2016)
  • Author(s): 福岡秀興，佐田文宏．
  • Journal Title: 日本衛生学雑誌 Volume: 71 Pages: 185-187
  • Peer Reviewed
• [Journal Article] 【講座 子どもを取り巻く環境と健康】第21回 環境化学物質曝露による先天異常への影響―先天性疾患，口唇口蓋裂． (2016)
  • Author(s): 宮下ちひろ，ホウマヌ・グウダルジ，岸 玲子．
  • Journal Title: 公衆衛生 Volume: 80 Pages: 863-867
• [Journal Article] 【講座 子どもを取り巻く環境と健康】第19回 妊娠中のカフェイン摂取の母児への影響． (2016)
  • Author(s): 佐田文宏，佐々木 成子，岸 玲子．
  • Journal Title: 公衆衛生 Volume: 80 Pages: 701-707
• [Journal Article] 【講座 子どもを取り巻く環境と健康】第18回 葉酸摂取の胎児発育や先天異常，生後アレルギーへの影響． (2016)
  • Author(s): 宮下ちひろ，伊藤久美子，荒木敦子，岸 玲子．
  • Journal Title: 公衆衛生 Volume: 80 Pages: 615-621
• [Journal Article] 【講座 子どもを取り巻く環境と健康】第17回 胎児期の化学物質曝露による後天的な遺伝子発現制御への影響． (2016)
  • Author(s): 宮下ちひろ，小林祥子，岸 玲子．
  • Journal Title: 公衆衛生 Volume: 80 Pages: 531-537
• [Presentation] 【小児環境保健疫学研究のパラダイム】２万人規模の大規模出生コホートと500人規模の小コホートが目指してきたものと成果． (2017)
  • Author(s): 岸 玲子．
  • Organizer: 第87回日本衛生学会学術総会
  • Place of Presentation: シーガイアコンベンションセンター（宮崎市）
  • Year and Date: 2017-03-26 – 2017-03-28
  • Invited
• [Presentation] 胎児期有機フッ素化合物曝露と臍帯血中アディポカイン濃度の関係：北海道スタディ． (2017)
  • Author(s): 湊屋街子，伊藤佐智子，宮下ちひろ，荒木敦子，佐々木成子，岩崎雄介，岸 玲子．
  • Organizer: 第87回日本衛生学会学術総会
  • Place of Presentation: シーガイアコンベンションセンター（宮崎市）
  • Year and Date: 2017-03-26 – 2017-03-28
• [Presentation] 胎児期BPA曝露による７歳までの喘鳴・アトピー性皮膚炎への影響：北海道スタディ． (2017)
  • Author(s): アイツバマイふゆ，宮下ちひろ，荒木敦子，湊屋街子，村松 徹，佐々木成子，岸 玲子．
  • Organizer: 第87回日本衛生学会学術総会
  • Place of Presentation: シーガイアコンベンションセンター（宮崎市）
  • Year and Date: 2017-03-26 – 2017-03-28
• [Presentation] ダイオキシン類の胎児期曝露による児のアレルギーへの影響：北海道スタディ． (2017)
  • Author(s): 宮下ちひろ，荒木敦子，伊藤佐智子，小林澄貴，アイツバマイふゆ，梶原淳睦，戸高 尊，岸 玲子．
  • Organizer: 第87回日本衛生学会学術総会
  • Place of Presentation: シーガイアコンベンションセンター（宮崎市）
  • Year and Date: 2017-03-26 – 2017-03-28
• [Presentation] 妊婦のコチニン値と出生体重との濃度依存的な関係に影響を及ぼすAHRとXRCC1遺伝子：北海道スタディ． (2017)
  • Author(s): 小林澄貴，佐田文宏，佐々木成子，Braimoh Tililola，荒木敦子，宮下ちひろ，Goudarzi Houman，小林祥子，岸 玲子．
  • Organizer: 第27回日本疫学会学術総会
  • Place of Presentation: ベルクラシック甲府（甲府市）
  • Year and Date: 2017-01-15 – 2017-01-17
• [Presentation] Association between prenatal phthalates and BPA exposures and fatal adipokines and birth size: the Hokkaido Study on Environment and Children’s Health. (2016)
  • Author(s): Machiko Minatoya, Atsuko Araki, Chihiro Miyashita, Jun Yamamoto, Yu Onoda, Toru Matsumura, Reiko Kishi.
  • Organizer: pptoxV
  • Place of Presentation: Kitakyusyu, Japan
  • Year and Date: 2016-11-13 – 2016-11-16
• [Presentation] .Prenatal exposure to organochlorine pesticides and steroid hormones profiles in fetal blood-the Hokkaido Study. (2016)
  • Author(s): Atsuko Araki, Chihiro Miyashita, Takahiko Mitsui, Houman Goudarzi, Sachiko Itoh, Futoshi Mizutani, Youichi Chisaki, Seiko Sasaki, Kimihiko Moriya, Kazutoshi Cho, Nobuo Shinohara, Katsuya Nonomura, Reiko Kishi.
  • Organizer: pptoxV
  • Place of Presentation: Kitakyusyu, Japan
  • Year and Date: 2016-11-13 – 2016-11-16
• [Presentation] エコチル調査北海道ユニットセンター詳細調査における環境測定． (2016)
  • Author(s): 西條泰明，川西康之，吉岡英治，伊藤俊弘，伊藤善也，小林澄貴，湊屋街子，岸 玲子．
  • Organizer: 第75回日本公衆衛生学会総会
  • Place of Presentation: グランフロント大阪（大阪市）
  • Year and Date: 2016-10-26 – 2016-10-28
• [Presentation] 家庭内での分煙行動と子どもの尿中コチニン値の関係：北海道スタディ． (2016)
  • Author(s): 西原進吉，小林澄貴，池野多美子，湊屋街子，岸 玲子．
  • Organizer: 第75回日本公衆衛生学会総会
  • Place of Presentation: グランフロント大阪（大阪市）
  • Year and Date: 2016-10-26 – 2016-10-28
• [Presentation] 母の妊娠中喫煙が児の出生体重，生後の発育に与える影響：北海道スタディ． (2016)
  • Author(s): 湊屋街子，小林澄貴，西原進吉，池野多美子，岸 玲子．
  • Organizer: 第75回日本公衆衛生学会総会
  • Place of Presentation: グランフロント大阪（大阪市）
  • Year and Date: 2016-10-26 – 2016-10-28
• [Presentation] Birth cohorts in Asia: why are new big cohorts functioning in Asia? (2016)
  • Author(s): Kishi R.
  • Organizer: 28th Annual Conference International Society for Environmental Epidemiology (ISEE2016)
  • Place of Presentation: Roma, Italy
  • Year and Date: 2016-09-01 – 2016-09-04
  • Invited
• [Presentation] Prenatal exposure to organochlorine pesticides and reproductive hormones in fetal blood: The Hokkaido Study. ISEE 2016. Roma, Italy. (2016.9.1-9.4) (2016)
  • Author(s): Atsuko Araki, Chihiro Miyashita, Sachiko Itoh, Takahiko Mitsui, Futoshi Mizutani,Yoichi Chisaki, Seiko Sasaki, Kazutoshi Cho, Katsuya Nonomura, Reiko Kishi.
  • Organizer: 28th Annual Conference International Society for Environmental Epidemiology (ISEE2016)
  • Place of Presentation: Roma, Italy
  • Year and Date: 2016-09-01 – 2016-09-04
• [Presentation] Epigenome-wide analyses of prenatal perfluoroalkyl acids exposure on cord blood DNA methylation: the Hokkaido study. (2016)
  • Author(s): Kobayashi, S., R. Miura, C. Miyashita, A. Araki, M. Ishizuka, H. Nakazawa, Y. Ito, T. Kubota, R. Kishi.
  • Organizer: 28th Annual Conference International Society for Environmental Epidemiology (ISEE2016)
  • Place of Presentation: Roma, Italy
  • Year and Date: 2016-09-01 – 2016-09-04
• [Presentation] Associated prenatal factors of behavioral and emotional problems in 5 year-old children: The Hokkaido Study. (2016)
  • Author(s): Minatoya, M., N. Tamura, S. Ito, C. Miyashita, A. Araki, R. Kishi.
  • Organizer: 28th Annual Conference International Society for Environmental Epidemiology (ISEE2016)
  • Place of Presentation: Roma, Italy
  • Year and Date: 2016-09-01 – 2016-09-04
• [Presentation] Prenatal exposure to DEHP and childhood wheeze and atopic dermatitis: The Hokkaido Study on the Environment and Children’s Health. (2016)
  • Author(s): Ait Bamai, Y., A. Araki, S. Sasaki, T. Nakajima, C. Miyashita, R. Kishi.
  • Organizer: 28th Annual Conference International Society for Environmental Epidemiology (ISEE2016)
  • Place of Presentation: Roma, Italy
  • Year and Date: 2016-09-01 – 2016-09-04
• [Presentation] Effects of prenatal exposure to perfluoroalkyl acids on risk of allergic and infections diseases in early life. (2016)
  • Author(s): Goudarzi, H., C. Miyashita, E. Okada, I. Kashino, S. Kobayashi, C.-J. Chen, S. Ito, A. Araki, H. Matsuura, R. Kishi.,
  • Organizer: 28th Annual Conference International Society for Environmental Epidemiology (ISEE2016)
  • Place of Presentation: Roma, Italy
  • Year and Date: 2016-09-01 – 2016-09-04
• [Presentation] DOHaD cohort studies and interventions: Current status and perspective. (2016)
  • Author(s): Sata F.
  • Organizer: ISEE-ISES AC2016
  • Place of Presentation: Sapporo, Japan
  • Year and Date: 2016-06-26 – 2016-06-29
• [Presentation] Prenatal Di(2-ethylhexyl)phthalate exposure and reproductive hormone in cord blood-The Hokkaido Study. (2016)
  • Author(s): Atsuko Araki and Reiko Kishi.
  • Organizer: ISEE-ISES AC2016
  • Place of Presentation: Sapporo, Japan
  • Year and Date: 2016-06-26 – 2016-06-29
• [Presentation] Hokkaido Study on Environment and Children’s Health: Endocrine Disruption Effect of Perfluoroalkyl Substances Exposure in Utero. (2016)
  • Author(s): Itoh, S., A. Araki, C. Miyashita, H. Goudarzi, S. Kato, Y. Iwasaki, H. Nakazawa, N. Shinohara, R. Kishi.
  • Organizer: ISEE-ISES AC2016
  • Place of Presentation: Sapporo, Japan
  • Year and Date: 2016-06-26 – 2016-06-29
• [Presentation] Hokkaido Study on Environment and Children’s Health: Overview, and Findings of PCBs/dioxins Exposure and Birth Size, & Allergies and Infections. (2016)
  • Author(s): Miyashita, C., R. Kishi, A. Araki.
  • Organizer: ISEE-ISES AC2016
  • Place of Presentation: Sapporo, Japan
  • Year and Date: 2016-06-26 – 2016-06-29
• [Presentation] Prenatal environment and child behavioral and coordination development at preschool age in the Hokkaido Study. (2016)
  • Author(s): Minatoya, M., N. Tamura, S. Itoh, S. Suyama, C. Miyashita, A. Araki, T. Saito, A. Nakai, R. Kishi.
  • Organizer: ISEE-ISES AC2016
  • Place of Presentation: Sapporo, Japan
  • Year and Date: 2016-06-26 – 2016-06-29
• [Presentation] Combined Effects on AHR, CYP1A1 and XRCC1 Genetic Polymorphisms and Prenatal Maternal Smoking on Infant Birth Size: The Hokkaido Study on Environment and Children’s Health. (2016)
  • Author(s): Kobayashi, S., F. Sata, S. Sasaki, T. S. Braimoh, A. Araki, C. Miyashita, H. Goudarzi, S. kobayashi, R. Kishi.
  • Organizer: ISEE-ISES AC2016
  • Place of Presentation: Sapporo, Japan
  • Year and Date: 2016-06-26 – 2016-06-29
• [Presentation] Allergic Disease in Relation to Phthalates and Phosphosphorus Flame Retardants in House Dust and Urine. (2016)
  • Author(s): Ait Bamai, Y., A. Araki, R. Kishi.
  • Organizer: ISEE-ISES AC2016
  • Place of Presentation: Sapporo, Japan
  • Year and Date: 2016-06-26 – 2016-06-29
• [Presentation] Epigenome-wide Pathway Analyses of Prenatal Perfluoroalkyl Acids Exposure on Cord Blood DNA Methylation: The Hokkaido Study. (2016)
  • Author(s): Kobayashi, S., R. Miura, C. Miyashita, A. Araki, M. Ishizuka, H. Nakazawa, Y. M. Ito, T. Kubota, R. Kishi.
  • Organizer: ISEE-ISES AC2016
  • Place of Presentation: Sapporo, Japan
  • Year and Date: 2016-06-26 – 2016-06-29
• [Presentation] 母の喫煙曝露と胎児発育との関連―遺伝的なハイリスクについて：北海道スタディ． (2016)
  • Author(s): 小林澄貴，佐田文宏，佐々木成子，Braimoh Titilola Serifat，荒木敦子，宮下ちひろ，Goudarzi Houman，小林祥子，岸 玲子．
  • Organizer: 第86回日本衛生学会学術総会
  • Place of Presentation: 旭川市民文化会館（旭川市）
  • Year and Date: 2016-05-11 – 2016-05-13
• [Presentation] 【次世代人材育成と今後の男女共同参画】胎児期～小児期の先制医療の重要性―DOHaDとライフコース・ヘルスケア． (2016)
  • Author(s): 佐田文宏．
  • Organizer: 第86回日本衛生学会学術総会
  • Place of Presentation: 旭川市民文化会館（旭川市）
  • Year and Date: 2016-05-11 – 2016-05-13
  • Invited
• [Remarks] 北海道大学環境健康科学研究教育センター 研究業績
  • URL: https://www.cehs.hokudai.ac.jp/research/