2017 Fiscal Year Final Research Report
Inflammatory responses triggered by inflammasome activation after exposure to carbon nanotubes
| Project/Area Number |
15K15236
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Hygiene and public health
|
|---|
| Research Institution | Jichi Medical University (2017)
Mie University (2015-2016) |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Keywords | 炎症 / ナノ素材 / 心血管系 / 安全性評価 |
|---|
| Outline of Final Research Achievements |
Apolipoprotein E-deficient (ApoE-/-) mice treated with double wall carbon nanotubes (DWCNTs) at the high dose showed increased plaque area in the aorta by oil red O staining. The expression of NLRP3, which is a central constitutive factor of inflammasome, and the expression of inflammatory factors (VCAM-1, ICAM-1) and cytokine (MCP-1) were significantly increased in ApoE-/- mice treated with long DWCNTs at the high dose. Furthermore, in human umbilical vein endothelial cells (HUVECs) treated with the high dose of DWCNTs the level of cytokine (IL-1β) was significantly elevated. The results suggested that DWCNTs induced the formation of arteriosclerotic lesion due to enhancing inflammatory responses triggered by inflammasome activation.
|
| Free Research Field |
環境衛生学
|
