2016 Fiscal Year Final Research Report
Gene-microbiota interaction of inflammatory bowel disease
| Project/Area Number |
15K15284
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | 炎症性腸疾患 |
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| Outline of Final Research Achievements |
To see the interaction between the genetic background and gut microbiota in Japanese patients with inflammatory bowel disease (IBD), we investigated the ‘typical’ signature of genetics and microbiota of IBD. The genetic background was known to be associated with IBD, but we found that it was associated with abnormal Paneth cells in Japanese CD. We also investigated the gut microbiota from 16 Japanese patients with ulcerative colitis, the diversity of microbiota was significantly different between the involved region and non-involved region even in the same patient. From the above, further analysis will be needed to prepare the model to see the gene-environmental interaction in IBD.
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| Free Research Field |
炎症性腸疾患
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