Development of experimental model of Chronic Intestinal Pseudo-obstruction (CIPO) using iPS and drug discovery research

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K15292
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Gastroenterology
• Research Institution: Osaka University
• Principal Investigator: Tsujii Masahiko 大阪大学, 医学系研究科, 招へい教授 (40303937)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 慢性偽性腸閉塞 / 便秘 / 過敏性腸症候群

Outline of Final Research Achievements

1) Clinical research of CIPO ( Chronic Intestinal Pseudo-obstruction)：An independent study of prospective multi center study analyzing prognostic factors of CIPO was accepted in 20 institutions (Osaka Gut Forum) led by Osaka University (endorsement number 13124). Fourteen cases have been enrolled to date: 10 females, 4 males. The large intestine was compromised in 13 cases. Four cases were treated with IVH, 6 were with surgery, and 5 were with decompression by endoscopy.
2) Analysis of concentration of serum protein APOB48: Concentration of serum protein APOB48 has been measured by immunoblotting analysis in 4 cases of CIPO, 3 cases of chronic constipation, and 3 healthy control.

Free Research Field

消化器内科学