2017 Fiscal Year Final Research Report
Identification of bile acid 6beta-hydroxylase in mouse liver
| Project/Area Number |
15K15300
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
本多 彰 東京医科大学, 医学部, 教授 (10468639)
宮崎 照雄 東京医科大学, 医学部, 講師 (60532687)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 胆汁酸 / ミュリコール酸 / マウス |
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| Outline of Final Research Achievements |
Mouse is the most commonly used animal for biomedical research. However, bile acid composition in mice is very different from that in humans. The most striking difference is a lack of chenodeoxycholic acid (CDCA) and the presence of muricholic acid (MCA) due to the activity of CDCA 6beta-hydroxylation in mice liver. In this study, we explored the enzyme that catalyzed 6beta-hydroxylation of CDCA and identified it as Cyp2c70. In addition, we made a mouse disrupted Cyp2c70 and confirmed that the mouse has CDCA instead of MCA.
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| Free Research Field |
消化器病学
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