Challenge for treatment of refractory lung diseases using a multifunctional envelope-type nanodevice that targets the lung endothelium

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K15315
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Respiratory organ internal medicine
• Research Institution: Hokkaido University
• Principal Investigator: Nishimura Masaharu 北海道大学, 医学研究科, 特任教授 (00208224)
• Co-Investigator(Renkei-kenkyūsha): AKITA Hidetaka 千葉大学, 大学院薬学研究院, 教授 (80344472)
• Research Collaborator: KIMURA Hiroki 北海道大学, 大学院医学研究科, 学術研究員 ; SANTIWARANGKOOL Sarochin 北海道大学, 大学院薬学研究院, 大学院生
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 核酸医薬 / 多機能性エンベロープナノ構造体 / siRNA

Outline of Final Research Achievements

We tried to knockdown lung tissue specific Keap1 mRNA using GALA-MEND containing Keap1 siRNA, but it was difficult to achieve its knockdown with good efficiency and specificity to the lung tissue. Then, we tried to improve the function of GALA-MEND by PEGylation. As a result, PEGylated GALA-MEND showed better accumulation to lung endothelial cells. This improved GALA-MEND is thought to be promising for future research.

Free Research Field

呼吸器内科学