Production of human induced bronchiolar progenitors

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K15316
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Respiratory organ internal medicine
• Research Institution: Niigata University
• Principal Investigator: KIKUCHI Toshiaki 新潟大学, 医歯学系, 教授 (10280926)
• Co-Investigator(Renkei-kenkyūsha): KANEHIRA Masahiko 東北大学, 大学病院, 助教 (90374941)
• Research Collaborator: SUZUKI Takuji 自治医科大学, 医学部, 准教授 (80344670) ; GOMI Kazunori コーネル大学 (20400335)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 前駆細胞

Outline of Final Research Achievements

The aim of this study is to establish the method of preparing mouse induced bronchiolar progenitor cells (referred to in the text as “iBP cells”), which will be applied to that of preparing human iBP cells. The achievement of this study is expected not only to provide mechanistic insights into the cell dedifferentiation specific to respiratory tract epithelial cells, but also to contribute to development of innovative medical technology by offering biomaterial indispensable for regenerative medicine. This grant support for 3 years enabled us to elucidate the characteristic feature of iBP cells and the molecular mechanism controlling the dedifferentiation step toward iBP cells.

Free Research Field

医学