Establishment and elucidation of a mathematical model that explains the pathogenesis of pulmonary alveolar proteinosis.

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K15321
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Respiratory organ internal medicine
• Research Institution: Niigata University
• Principal Investigator: NAKATA Koh 新潟大学, 医歯学総合病院, 教授 (80207802)
• Co-Investigator(Kenkyū-buntansha): 田澤 立之 新潟大学, 医歯学総合病院, 准教授 (70301041) ; 北村 信隆 新潟大学, 医歯学総合病院, 特任教授 (90224972) ; 井上 義一 独立行政法人国立病院機構(近畿中央胸部疾患センター臨床研究センター), 臨床研究センター, 臨床研究センター長 (90240895)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 自己免疫性肺胞蛋白症 / 抗GM-CSF自己抗体 / 内因性GM-CSF / 免疫複合体 / 全肺洗浄法

Outline of Final Research Achievements

During whole lung lavage, the concentration of GM-CSF autoantibody in the lavage fluid decreased serially to 0.1% of the first lavage fluid, whereas GM-CSF production by alveolar type II cells remained and form immune complex with GM-CSF autoantibody entered into the alveoli from the blood. The complex may be gradually absorbed by macrophages. These reactions can be expressed as a mathematical equations. Here, we noticed that the initial conditions such as GM-CSF production level and number of GM-CSF autoantibody molecules affect the simulation by the equations.

Free Research Field

呼吸器内科学