2017 Fiscal Year Final Research Report
Development of a periostin detection kit of next generation
| Project/Area Number |
15K15372
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Collagenous pathology/Allergology
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| Research Institution | Saga University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
太田 昭一郎 佐賀大学, 医学部, 研究講師 (20346886)
有馬 和彦 佐賀大学, 医学部, 助手 (60336112)
小川 雅弘 佐賀大学, 医学部, 助教 (90599317)
南里 康弘 (宮内康弘) 佐賀大学, 医学部, 研究助教 (00382218)
布村 聡 佐賀大学, 医学部, 准教授 (70424728)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | アトピー性皮膚炎 / 喘息 |
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| Outline of Final Research Achievements |
Although it is known that periostin is useful as a biomarker for various diseases, it has a problem in the specificity for diseases. This study aimed at constructing a disease-specific periostin detection kit. We first found that periostin exists as both oligomers and monomers in serum. We next found that two monoclonal anti-periostin antibodies, SS19D and SS19A, recognize only monomeric periostin. We, furthermore, found that monomeric periostin is superior in the abilities to diagnose idiopathic pulmonary fibrosis (IPF) and to predict its poor prognosis of lung functions compared to its conventional biomarkers. These results suggest that measurement of monomeric periostin is useful for diagnosis and treatment of IPF patients.
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| Free Research Field |
アレルギー学
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