The development of anti-allergy therapies targeting several inhibitory receptors

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K15376
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Collagenous pathology/Allergology
• Research Institution: Juntendo University
• Principal Investigator: Kitaura Jiro 順天堂大学, 医学(系)研究科(研究院), 先任准教授 (30282651)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: アレルギー / 抑制型受容体 / 脂質

Outline of Final Research Achievements

Binding and reporter assays using an extracellular domain of inhibitory receptors showed that mast cell inhibitory receptors tested, except for LMIR1 and LMIR3, failed to recognize specific lipids. While the binding of ceramide to LMIR3 inhibited FceRI signals in vitro and in vivo, the interaction between phosphatidylserine and LMIR1 failed to do so. Accordingly, the inhibitory effect of vesicles containing both ceramide and phosphatidylserine on FceRI-mediated mast cell activation was weaker than that of vesicles containing ceramide alone. Thus, administering vesicles containing lipid ligands for LMIR3 might be effective for allergic diseases.

Free Research Field

アレルギー・免疫学