Establish of novel therapy for DIC and multiple organ failures with apolipoprotein M

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K15378
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Infectious disease medicine
• Research Institution: The University of Tokyo
• Principal Investigator: Kurano Makoto 東京大学, 医学部附属病院, 講師 (60621745)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 敗血症 / DIC / 多臓器不全 / アポ蛋白M / スフィンゴシン1－リン酸

Outline of Final Research Achievements

We found that the overexpression of apolipoprotein M (ApoM), an apolipoprotein carried on HDL, ameliorated the survival rate and organ injuries caused by the treatment with lipopolysaccharides, while the suppression of apoM deteriorated them. Moreover, we successfully improved the outcomes of the injection with lipopolysaccharides with recombinant apoM. These findings suggest that apoM can be applied to the treatment with DIC and/or multiple organ failure which occur consequently to sepsis.

Free Research Field

脂質学