Regulation of digit development by transcription factors

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K15387
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Pediatrics
• Research Institution: Shiga University of Medical Science (2016); Tokyo Medical and Dental University (2015)
• Principal Investigator: Mori Masaki 滋賀医科大学, 神経難病研究センター, 特任准教授 (10602625)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 形態形成 / 指芽発生 / パターニング / 転写因子 / 遺伝子ネットワーク / 発生学

Outline of Final Research Achievements

Limb bud patterning, outgrowth, and differentiation are precisely regulated in a spatio-temporal manner through integrated networks of transcription factors, signaling molecules, and downstream genes. However, the exact mechanisms that orchestrate morphogenesis of the limb remain to be elucidated. We focused our expression pattern analysis on a selection of transcription factor genes that exhibit spatially localized and temporally dynamic expression patterns with respect to the anterior-posterior axis in the E9.5-11.5 limb bud. In this project, we identified Hesr1/2 and Irx3 as the key genes that regulate the digit development.

Free Research Field

小児科学