Effect of repetitive and transcranial near infrared irradiation on inflammatory processes in the brain of rats.

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K15426
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: Takahashi Taro 浜松医科大学, 医学部, 特任助教 (30402358)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: Low level Laser therapy / BDNF / インターロイキン

Outline of Final Research Achievements

Immune activation processes including microglial activation in the brain have been implicated in the pathology of neurodevelopmental disorders such as schizophrenia and autism. Low-level laser therapy (LLLT) has been used in the treatment of inflammatory pathologies. In this study we examined possible therapeutic effects of LLLT on immune activations in the rat brain of offspring of dams exposed to poly I:C and GM-CSF. The immune activation in the rat brain wasn’t shown between poly I:C, GM-CSF and control group. However, the expression levels of BDNF were shown to increase while several cytokine (IL-1β, IL-6, IL-10) were shown to decrease after LLLT on the normal rat frontal cortex by using RT-PCR. Similarly the rat body temperature tended to elevated after LLLT. Especially activation of BDNF expression by LLLT was shown in rat pup brain and human neuroblastoma cell (SK-N-SH).The result suggests LLLT may affect brain function through modulation of expression BDNF and cytokine.

Free Research Field

神経行動学