2016 Fiscal Year Final Research Report
Development of biomarker related to gender dysphoria (gender identity disorder) based on whole exome sequencing analysis.
| Project/Area Number |
15K15433
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Psychiatric science
|
|---|
| Research Institution | Saitama Medical University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
KOH Jun 大阪医科大学, 医学部, 准教授 (40257853)
OKAZAKI Yasushi 埼玉医科大学, 医学部, 教授 (80280733)
|
|---|
| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Keywords | 性同一性障害 / 性別違和 / 全エクソーム解析 / 全ゲノム解析 / 変異・多型 |
|---|
| Outline of Final Research Achievements |
This research project was a research plan based on whole-exome analysis of the Gender Identity Disorder/Gender Dysphoria (GID) genome DNA. However, several polymorphisms other than the exon region, which are implied to be related to gender identity disorder, have been reported from foreign research groups. Since it is not possible to detect variants and polymorphisms only up to the flanking range of about 100 bp of the exon region with the original plan, it is necessary to change the method to the whole-genome sequencing analysis and re-analyze our samples. Detection of repetitive sequence polymorphisms found in intron regions and intergenic regions by preliminary analysis was also feasible enough for whole-genome analysis, therefore total genome analysis was performed on ten GID samples by changing the method.
|
| Free Research Field |
分子生物学、ゲノム科学、バイオインフォマティクス
|
