Search of organ specific tumor markers by N-glycan expression in pancreatic cancer

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K15501
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Digestive surgery
• Research Institution: Kagoshima University
• Principal Investigator: Natsugoe Shoji 鹿児島大学, 医歯学域医学系, 教授 (70237577)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 膵臓癌 / N型糖鎖 / 腫瘍マーカー

Outline of Final Research Achievements

We analyzed the serum N-glycan in 17 pancreatic cancer patients and 11 healthy volunteers. N-glycan expression by using OPLS method was stratified between pancreatic cancer patients and healthy volunteers on the base of glycan expression pattern. We extracted six N-glycan with statistical significance between pancreatic cancer patients and healthy volunteers. According to these six markers, four markers was ascertained by duplication test. These results show that these N-glycan may be a useful markers in early detection of pancreatic cancer and relapse disease.

Free Research Field

消化器外科