2016 Fiscal Year Final Research Report
Function of (pro)renin receptor in human iPS cell.
| Project/Area Number |
15K15511
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cardiovascular surgery
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| Research Institution | Saitama Medical University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Keywords | （プロ）レニン受容体 / iPS細胞 / 中胚葉誘導 / WNTシグナル |
|---|
| Outline of Final Research Achievements |
(Pro)renin receptor is one molecule of Renin angiotensin system (RAS), and non proteolically evokes renin activity of prorenin, while there are several articles that show RAS independent functions of (P)RR. We found that (P)RR was highly expressed in human iPS cell. Full-length (P)RR was mainly localized in the nucleus and might play an important role in differentiation induction of human iPS cell.
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| Free Research Field |
心不全、再生医療、細胞内伝達情報
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