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2016 Fiscal Year Final Research Report

Function of (pro)renin receptor in human iPS cell.

Research Project

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Project/Area Number 15K15511
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Cardiovascular surgery
Research InstitutionSaitama Medical University

Principal Investigator

Senbonmatsu Takaaki  埼玉医科大学, 医学部, 教授 (70216563)

Project Period (FY) 2015-04-01 – 2017-03-31
Keywords(プロ)レニン受容体 / iPS細胞 / 中胚葉誘導 / WNTシグナル
Outline of Final Research Achievements

(Pro)renin receptor is one molecule of Renin angiotensin system (RAS), and non proteolically evokes renin activity of prorenin, while there are several articles that show RAS independent functions of (P)RR. We found that (P)RR was highly expressed in human iPS cell. Full-length (P)RR was mainly localized in the nucleus and might play an important role in differentiation induction of human iPS cell.

Free Research Field

心不全、再生医療、細胞内伝達情報

URL: 

Published: 2018-03-22  

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