Effects of Perfluorocarbon on the re-perfuion injury of the donor lungs

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K15515
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Respiratory surgery
• Research Institution: The University of Tokyo
• Principal Investigator: Nakajima Jun 東京大学, 医学部附属病院, 教授 (90188954)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 温虚血 / 移植 / ドナーグラフト / 虚血再灌流

Outline of Final Research Achievements

Perfluorocarbon(PFC) has been studied in the field of transplantation but has never been used to reduce re-perfusion injury of the implanted lungs. Therefore, we investigated whether PFC can ameliolate the injury after lung transplantaion using our rat transplant model. It seemed that PFC could cause tissue inflamation represented by increase of mRNA expression of CXCL-1, but no significant protective effects to hypoxic tissue injuries measued by hipoxia-induced factor 1-alpha and 2-alpha. We are going to examine its efects on anti-tissue damage in the setting of ev-vivo perfusion of the grafts.

Free Research Field

肺移植