Gait analyses of osteoarthritis model mice for joint pain assessment

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K15535
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Orthopaedic surgery
• Research Institution: The University of Tokyo
• Principal Investigator: SAITO Taku 東京大学, 医学部附属病院, 講師 (30456107)
• Co-Investigator(Kenkyū-buntansha): 柳原 大 東京大学, 大学院総合文化研究科, 准教授 (90252725)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 整形外科学 / 変形性関節症

Outline of Final Research Achievements

Joint pain is the most common symptom of OA, however, molecular mechanisms of pain in OA joint have been generally unrevealed. Here, we performed the motion analysis of surgically-induced OA model mice to examine how cartilage degeneration of the knee joint alters gait and joint motions. Locomotion recording and Motion analyses were performed at six months after osteoarthritis surgery. Among all parameters, the degree of knee flexion in the stepping-in phase was significantly changed in the OA group.

Free Research Field

整形外科学