The role of endothelial microparticles in ARDS

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K15562
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Anesthesiology
• Research Institution: Tohoku University
• Principal Investigator: Saito Kouji 東北大学, 大学病院, 准教授 (10359515)
• Co-Investigator(Renkei-kenkyūsha): Takei Yusuke 東北大学, 大学病院, 助教 (80822890)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: ARDS / 内皮微小粒子 / 血管内皮傷害 / 敗血症

Outline of Final Research Achievements

We investigated the role of the angiotensin+ endothelial microparticles (ACE+EMPs) as a pulmonary endothelial injury. More ACE+EMPs were released from Human pulmonary microvascular endothelial cells than other endothelial cells and increased by inflammatory stimuli. Circulating ACE+EMPs were significantly higher in septic patients with ARDS than patients without ARDS. Furthermore, ACE+EMPs increased significantly in mouse lung injury model and correlate with the severity of pulmonary microvascular permeability. Circulating ACE+ EMPs could therefore be a useful marker for evaluating pulmonary endothelial injury during ARDS.

Free Research Field

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