Elucidation of molecular mechanisms of the anesthetic action regarding fear memory constitution

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K15575
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Anesthesiology
• Research Institution: Aichi Medical University
• Principal Investigator: Kinoshita Hiroyuki 愛知医科大学, 公私立大学の部局等, 客員研究員 (70291490)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 麻酔薬 / 記憶 / 思春期 / 脳

Outline of Final Research Achievements

The current study was designed to evaluate whether the inhalation of volatile anesthetic sevoflurane (2.5% for 3 hours) enhances the long-term fear memory learning ability in combination with the F-actin constitution as well as rac-1 protein expression in the hippocampus in four-weeks-old young adult mice. Sevoflurane exposure to young adult mice accelerated the long-term fear memory with the increased F-actin constitution and rac-1 protein expression in the hippocampus. These results indicate that sevoflurane may enhance fear memory consolidation in young adults of humans.

Free Research Field

麻酔科学