2016 Fiscal Year Final Research Report
A development of new renal carcinoma treatment using the nano-material
| Project/Area Number |
15K15589
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Urology
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
Fujii Hidetaka 京都府立医科大学, 医学(系)研究科(研究院), 客員講師 (10405318)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | 腎細胞癌 / VEGF-A / siRNA / DDS / 腫瘍免疫 / 免疫抑制性細胞 |
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| Outline of Final Research Achievements |
We developed a new gene therapy for renal cell carcinoma(RCC), using the siRNAs and nanogel.The siVEGF-A/nanogel complex was engulfed by RCC, resulting in efficient knockdown of VEGF-A. In addition, it appears that the complex is stably maintained in tumor tissue.
Intra-tumor injections of the complex significantly suppressed neovascularization and growth of RCC in mice. The treatment also inhibited induction of myeloid-derived suppressor cells (MDSCs)。These results suggest that local suppression of VEGF-A may have a positive impact on systemic immune responses against malignancies.
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| Free Research Field |
腎細胞癌局所療法
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