2016 Fiscal Year Final Research Report
A novel mechanism of the peritoneal dissemination via multiple network among cellular skeleton-related molecules in ovarian cancer
Project/Area Number |
15K15604
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Obstetrics and gynecology
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Research Institution | Nagoya University |
Principal Investigator |
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Co-Investigator(Renkei-kenkyūsha) |
SENGA Takeshi 名古屋大学, 大学院医学系研究科, 准教授 (80419431)
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Project Period (FY) |
2015-04-01 – 2017-03-31
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Keywords | 卵巣癌 / 腹膜播種 / 腹膜中皮細胞 |
Outline of Final Research Achievements |
Epithelial ovarian carcinoma (EOC) is believed to cause peritoneum dissemination through microenvironmental cell-to-cell communication between the tumor and mesothelium, leading to the further acquisition of progressive and metastatic potentials. In the present study, we aimed to determine the role of cancer-associated mesothelial cells (CAMCs) in the maintenance of cisplatin-resistance. Normal mesothelium (MC) showed an epithelial morphology with a cobblestone appearance. When MCs were co-cultured with malignant ascites from patients with advanced EOC, a dramatic morphologic change was noted from an epithelioid pattern to a-SMA-positive fibroblastic, mesenchymal pattern. Our findings indicate the possible involvement of CAMCs in the maintenance of cisplatin-resistance, resulting in being “seeds of recurrence”. The novel mechanism of CAMCs as a facilitator of EOC progression is displayed through microenvironmental cell-to-cell communication between EOC and the mesothelium.
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Free Research Field |
婦人科腫瘍学
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