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2017 Fiscal Year Final Research Report

Diaphragmatic regeneration using umbilical cord blood derived stem cels for diaphragmatic agenesis

Research Project

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Project/Area Number 15K15646
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Pediatric surgery
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

Tajiri Tatsuro  京都府立医科大学, 医学(系)研究科(研究院), 教授 (80304806)

Co-Investigator(Kenkyū-buntansha) 岸田 綱郎  京都府立医科大学, 医学(系)研究科(研究院), 准教授 (00370205)
木村 修  京都府立医科大学, 医学(系)研究科(研究院), 特任教授 (10315963)
東 真弓  京都府立医科大学, 医学(系)研究科(研究院), 助教 (10380453)
文野 誠久  京都府立医科大学, 医学(系)研究科(研究院), 助手 (40405254)
Project Period (FY) 2015-04-01 – 2018-03-31
Keywords再生医学 / 小児外科 / 先天性横隔膜ヘルニア / 骨格筋 / 臍帯血
Outline of Final Research Achievements

Diaphragmatic regeneration using umbilical cord blood derived stem cels for diaphragmatic agenesis was attempted using 3 types of different stem cells. Connection of small muscle sphere was not observed. Therefore, we attempted direct conversion from human fibroblast into myoblast using MyoD1 and L-myc gene trasfection as next step. Finally, we obtained
multinucleated muscle cells with high efficiency. we perspective function myosheet using this novel technique.

Free Research Field

医歯薬学

URL: 

Published: 2019-03-29  

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