2016 Fiscal Year Final Research Report
identification of role of endoplasmic reticulum stress response in synoviocyte and its application to the treatment of temporomandibular disorder.
| Project/Area Number |
15K15685
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Functional basic dentistry
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | ストレス応答 |
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| Outline of Final Research Achievements |
Although temporomandibular joint disease develops with various causes, common pathological findings are the overgrowth and activation of synovial cell. The E3 ubiquitin ligase Synoviolin / HRD1 involved in endoplasmic reticulum quality control has been identified as the cause of this synovial cell overgrowth. We have studied the mechanism of the endoplasmic reticulum quality control mechanism. Our results suggest that HRD1 is post-translationally modified by the ubiquitin-like protein NEDD8 and its activation is controlled by its neddylation. In this study, we clarified the mechanism of HRD1 activation by the post-translational modification. Our knowledge may shed light on the to the development of novel treatment for temporomandibular disorder.
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| Free Research Field |
細胞生物学
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