2016 Fiscal Year Final Research Report
Vertical Bone Augmentation Using iPS Cell Constructs with CAD/CAM Dome
| Project/Area Number |
15K15705
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Prosthodontics/ Dental materials science and
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | 再生医療 |
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| Outline of Final Research Achievements |
It was revealed that the PKC inhibitor (isoH-7) promotes osteogenic differentiation of iPS cells. We also examined the mold design of dome type titanium membrane using CAD / CAM, and fabricated the mold for vertical bone augmentation. Furthermore, iPS cell aggregates differentiated into osteoblasts by adding PKC inhibitor were transplanted into the back of mouse. As the result, tumor formation was confirmed, but the tumor size became smaller as compared with that induced without PKC inhibitor. It was suggested that by improving the protocol it could be a new bone formation methods using autologous iPS cells combined with the vertical bone augmentation mold.
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| Free Research Field |
歯科補綴学・再生医学
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