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2017 Fiscal Year Final Research Report

Study on mastication dysfunction-induced memory impairment

Research Project

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Project/Area Number 15K15712
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Prosthodontics/ Dental materials science and
Research InstitutionNagoya City University

Principal Investigator

Michikawa Makoto  名古屋市立大学, 大学院医学研究科, 教授 (40270912)

Co-Investigator(Kenkyū-buntansha) 赤川 安正  奥羽大学, 歯学部, 教授 (00127599)
大上 博史  広島大学, 医歯薬保健学研究科(歯), 助教 (70711307)
小野 卓史  東京医科歯科大学, 大学院医歯学総合研究科, 教授 (30221857)
Project Period (FY) 2015-04-01 – 2018-03-31
Keywords認知症 / 歯牙欠損 / 咀嚼機能低下 / BDNF
Outline of Final Research Achievements

The relationship between teeth loss or mastication dysfunction and dementia including Alzheimer’s disease has been reported. However, the molecular mechanism underlying these remain unknown. In this study we have examined teeth loss-induced and mastication dysfunction-induced memory impairment using mice and identified the mechanisms.

Free Research Field

生化学

URL: 

Published: 2019-03-29  

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