Study on mastication dysfunction-induced memory impairment

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K15712
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Prosthodontics/ Dental materials science and
• Research Institution: Nagoya City University
• Principal Investigator: Michikawa Makoto 名古屋市立大学, 大学院医学研究科, 教授 (40270912)
• Co-Investigator(Kenkyū-buntansha): 赤川 安正 奥羽大学, 歯学部, 教授 (00127599) ; 大上 博史 広島大学, 医歯薬保健学研究科(歯), 助教 (70711307) ; 小野 卓史 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (30221857)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 認知症 / 歯牙欠損 / 咀嚼機能低下 / BDNF

Outline of Final Research Achievements

The relationship between teeth loss or mastication dysfunction and dementia including Alzheimer’s disease has been reported. However, the molecular mechanism underlying these remain unknown. In this study we have examined teeth loss-induced and mastication dysfunction-induced memory impairment using mice and identified the mechanisms.

Free Research Field

生化学