Explore for master regulator of EMT in oral cancer

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K15740
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: The University of Tokushima
• Principal Investigator: TSUNEMATSU Takaaki 徳島大学, 大学院医歯薬学研究部(医学系), 助教 (70726752)
• Co-Investigator(Renkei-kenkyūsha): ISHIMARU Naozumi 徳島大学, 大学院医歯薬学研究部, 教授 (60314879) ; ARAKAKI Rieko 徳島大学, 大学院医歯薬学研究部, 准教授 (00193061)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 口腔扁平上皮癌 / EMT

Outline of Final Research Achievements

It is known that Epithelial Mesenchymal Transition, EMT is important step in cancer invasion and metastasis. Interestingly, there are spindle cell carcinoma with EMT phenotype known as the subtype of oral squamous cell carcinoma . In this study, we tried to explore the master regulator of EMT by using spindle cell carcinoma cell lines which we previously established. We could not identify the master regulator of EMT but established the spindle cell carcinoma cell line with reporter gene. In future, we try to identify the master regulator of EMT by using this reporter cell line.

Free Research Field

実験腫瘍学