Involvement of SPARC-mediated cell competition on carcinogenesis of oral squamous cell carcinoma

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K15743
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: Kochi University
• Principal Investigator: Yamamoto Tetsuya 高知大学, 教育研究部医療学系臨床医学部門, 教授 (00200824)
• Co-Investigator(Kenkyū-buntansha): 笹部 衣里 高知大学, 教育研究部医療学系臨床医学部門, 講師 (40363288) ; 北村 直也 高知大学, 教育研究部医療学系臨床医学部門, 講師 (70351921)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 細胞競合 / 扁平上皮癌 / SPARC

Outline of Final Research Achievements

We previously reported that SPARC plays important roles in the development and progression of oral squamous cell carcinoma (OSCC) through avoidance from exclusion of loser cells at cell competition. In this study, we examined the involvement of SPARC in malignant potentials of OSCC. Transfection of SPARC expression vector into OSCC cells and the immortalized oral mucosal epithelial cells resulted in enhanced proliferative capacity and exclusion of control cells in the co-culture system of SPARC overexpressed cells and control cells. On the other hands, the ability of adhesion, invasion, and migration were not affected, suggesting that SPARC may not be involved in malignant potentials of OSCC.

Free Research Field

口腔外科学