2017 Fiscal Year Final Research Report
An analysis of therapeutic and functional efficiency of targeting Janus kinase and periodontal bacteria in patients with periodontitis and rheumatoid arthritis
| Project/Area Number |
15K15764
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Periodontology
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
小林 哲夫 新潟大学, 医歯学総合病院, 准教授 (00215344)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 歯周炎 / 関節リウマチ / JAK分子標的 / 抗菌療法 |
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| Outline of Final Research Achievements |
The aim of the present study was to assess the therapeutic and functional efficiency of targeting Janus kinase (JAK) and periodontal bacteria in patients with periodontitis and rheumatoid arthritis (RA). The results indicated that both the JAK- and the periodontal bacteria-targeting therapies exhibited an improvement of rheumatologic and periodontal inflammatory condition. The former therapies reduced serum levels of interleukin-6 and tumor necrosis factor, while the latter decreased serum protein spots in abundance which corresponds to blood and lipid metabolism-related components including apolipoprotein A1, angiotensinogen, and hemopexin. These results suggest the beneficial therapeutic effects of the JAK- and the periodontal bacteria-targeting therapies on rheumatologic and periodontal condition in patients with periodontitis and RA.
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| Free Research Field |
歯周病学
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