Research for relationship between oral microboiome and head and neck and digestive organ cancers

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K15774
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Social dentistry
• Research Institution: Kyushu University
• Principal Investigator: Yamashita Yoshihisa 九州大学, 歯学研究院, 教授 (20192403)
• Co-Investigator(Renkei-kenkyūsha): TOU Yasushi 独立行政法人国立病院機構, 副病院長 (20217459) ; MORITA Masaru 独立行政法人国立病院機構, 消化器外科, 科長 (30294937) ; MASUDA Muneyuki 独立行政法人国立病院機構, 頭頸部外科, 科長 (90284504)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 歯学 / 細菌 / 口腔マイクロバイオーム / 頭頸部がん / 消化器がん

Outline of Final Research Achievements

The purpose of this study is the characterization of the oral microbiome related to head and neck, digestive organ cancer. Saliva was collected from the patients who had a diagnosis of head and neck cancer or a digestive organ cancer in National Hospital Organization Kyushu Cancer Center. Salivary microbiome was analyzed with the next-generation sequencer. The results were compared with those of the salivary microbiome of dwelling population at Hisayama town to aim the identification of a special microbe or the unique constitution pattern to cancer patients. As a result, the salivary microbiome constitution peculiar to the patients of head and neck, digestive organ cancer was not recognized, but the constituent ratio of some bacterial species was significantly different between a cancer patients and non-cancer dwelling population.

Free Research Field

口腔衛生学