2016 Fiscal Year Final Research Report
The role of astrocyte lipid rafts in mental disorder induced by a lack of nutrition
| Project/Area Number |
15K16206
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Eating habits
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | 脂肪酸結合蛋白質 / FABP7 / アストロサイト / 脂質ラフト / caveolin-1 / 神経可塑性 |
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| Outline of Final Research Achievements |
Recently, the relationship between higher brain functions and neurological disorder has been paid attention. It is reported that a lack of nutrition such as n-3 polyunsaturated fatty acids (PUFAs) induces mental disorders, but its mechanism is still unknown. In this study, we focused the fatty acid binding protein (FABP7) which is highly expressed in astrocytes and has high affinity with n-3 PUFAs. We examined whether FABP7 is involved in the functions of lipid rafts which is the main source of cellular activity in response to external stimuli. The following results have been so far obtained: 1. FABP7 controls lipid raft function through regulation of caveolin-1 expression and is involved in the response of astrocytes to the external stimuli, 2. altered production of humoral factors from FABP7-KO astrocytes induced neuroplasticity changes.
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| Free Research Field |
神経科学、分子生物学
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