The role of ER stress in fatty liver: Identification of novel fatty acid sensing molecule

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K16208
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Eating habits
• Research Institution: National Institute of Advanced Industrial Science and Technology (2017); The University of Tokushima (2015-2016)
• Principal Investigator: ABE TOMOKI 国立研究開発法人産業技術総合研究所, 生命工学領域, 研究員 (00736605)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 脂肪肝 / ユビキチンリガーゼ / 小胞体ストレス / 脂肪合成

Outline of Final Research Achievements

Fatty liver is associated with cirrhosis and hepatic cacinoma, although molecular mechanisms for fatty liver remain unclear. The aim of this study was to elucidate the pathophysiological role of Cbl-b, one of ubiquitin ligases in the fatty liver induced by nutritional excess in mice. I found that depletion of Cbl-b exacerbate fatty liver in mice fed high-fat diet for 8 weeks. In livers of Cbl-b deficient mice, ER stress and expressions of lipogenesis-associated genes were upregulated. Cbl-b might be a potent target to prevent and improve for fatty liver.

Free Research Field

分子栄養学