2016 Fiscal Year Final Research Report
Investigation of mechanism of dietary ligands-TRPA1 interactions
Project/Area Number |
15K16212
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Eating habits
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Research Institution | Okayama University |
Principal Investigator |
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Project Period (FY) |
2015-04-01 – 2017-03-31
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Keywords | フラボノイド / イソチオシアネート / TRPA1 |
Outline of Final Research Achievements |
We investigated the interaction between TRPA1 and food compounds. We indicated some novel agonists of TRPA1 such as Kaempferol and Myricetin. In addition, the agonistic activities of several major quercetin glycosides and metabolites towards TRPA1 were also evaluated. Methylated quercetin activated TRPA1 receptor. To identify the site of interaction of these flavonoids and TRPA1, we attempted to prepare the monoclonal antibodies to flavonoids. We developed a novel monoclonal antibody using dihydroxyphenylacetic acid as an immunogen.
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Free Research Field |
食品機能学
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