Development of a new stroke rehabilitation strategy; regulation of interhemispheric inhibition by paired associative stimulation

2018 Fiscal Year Final Research Report

• Project/Area Number: 15K16360
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Ibaraki Prefectural University of Health Science
• Principal Investigator: Yamamoto Satoshi 茨城県立医療大学, 保健医療学部, 助教 (00735334)
• Research Collaborator: Ishii DAISUKE 茨城県立医療大学, 医科学センター, 助教 ; Ishibashi KIYOSHIGE 茨城県立医療大学大学院, 保健医療科学研究科, 院生 ; Kohno YUTAKA 茨城県立医療大学, 医科学センター, 教授
• Project Period (FY): 2015-04-01 – 2019-03-31
• Keywords: 連合性ペア刺激 / 脳卒中片麻痺 / 半球間抑制 / 経頭蓋磁気刺激 / 安静時fMRI

Outline of Final Research Achievements

Paired associative stimulation (PAS25) is a stimulation series that combines transcranial magnetic stimulation (TMS) to M1 following peripheral nerve electrical stimulation. There are a few studies focusing on the effect of PAS25 on opposite M1. 1) The significant change of interhemispheric inhibition was observed by PAS25. 2) The significant change of functional connectivity within each M1 were observed by PAS25.

Free Research Field

神経生理学

Academic Significance and Societal Importance of the Research Achievements

本研究によって提案されたPAS25の評価方法は，今後のPAS25の臨床応用に有用な知見となると考えられる。